|
KMID : 0881720210360010100
|
|
Journal of Food Hygiene and Safety
2021 Volume.36 No. 1 p.100 ~ p.104
|
|
|
trans-Cinnamaldehyde-Induced Apoptosis in AGS Cells
|
|
Lee Sun-Yi
Jung Joo-Hee
|
|
|
Abstract
|
|
|
|
trans-Cinnamaldehyde (TCA), as one of the active ingredients in cinnamon, has been reported to have antiviral, antibacterial and antifungal effects as well as anti-cancer effects in several cancer cell lines. However, reports of TCA in gastric cancer are rare, and its mechanism is unclear. In this study, we investigated the anti-proliferative effect of TCA and its mechanism in gastric cancer AGS cells. TCA dose-dependently inhibited the cell viability of AGS cells. Our results suggested that TCA induces apoptosis through changes in cell morphology. To elucidate its mechanism, we investigated the expression level of apoptosis-related proteins. TCA induced the expression of p53 and Bax proteins, and then increased the cleaved caspase 9 and cleaved PARP. These results indicated that TCA triggers apoptosis via p53 pathway in AGS cells. Our results suggested that TCA might be a new anticancer drug candidate for gastric cancer.
|
|
|
KEYWORD
|
|
|
trans-cinnamaldehyde, Gastric cancer AGS cell, Apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|